Definition:

"The antithesis is a theological principle that is meant to describe the difference between believers and unbelievers. There are many ways that we could describe that difference, but we must at the very least describe that difference covenantally. That is, it describes a distinction between those who are in Adam and under the terms of the covenant of works and those who are in Christ—those who Christ has redeemed and brought into the covenant of grace. There is a covenantal distinction between these groups."
-Camden M. Bucey [source]

Biblical Exposition:

"Understanding of the antithesis between the people of God and the people of the world is the sine qua non to the very message and prophecy of the fulfilling work of Christ. Christ's Word is, from beginning to end, replete with verses which speak of, imply, or underscore this fundamental antipathy, whether philosophically in terms of controlling worldviews (Col. 2:8), particular epistemologies (Rom. 8:7; cf. Prov. 1:7; 9:10), or conflicting ethical standards on how man should live (Rom. 1:26-32; cf. Gal. 5:19-21)."
-Joshua Pillows [source]

Key Scriptures: Genesis 3:15; 2 Corinthians 6:15